Sentence examples for modulated pathways were from inspiring English sources
Instead the vast majority of differentially modulated pathways were equally distributed between the specific exposure conditions.
Of note, most of the modulated pathways were immune-related (e.g., altered T cell and B cell signaling in rheumatoid arthritis, dendritic cell maturation and Toll-like receptor and TREM1 signaling), suggesting the suppression of immune function at this early time point.
Although discussing each of the modulated pathways is beyond the scope of this study, some notable generalizations can be addressed.
Similarly modulated common pathways were identified between in vitro and in vivo.
Those modulated signaling pathways were comprised of ribosome, Alzheimer's disease, asthma, oxidative phosphorylation, focal adhesion, ECM-receptor interaction, C21-Steroid hormone metabolism, metabolic pathways, and prostate cancer (Table 4).
The distribution into each functional category of proteins whose abundance varied significantly, and the modulated metabolic pathways, are shown in Figures 4 and 5 respectively.
In both cases significantly differentially modulated pathways have been identified by a combination of dimension reduction via Principal Coordinates with Hotelling's multivariate extension of the t-test.
Using a large dataset of CRC miRNA and gene expression profiles, we describe the interplay of miRNA groups in regulating gene expression, which in turn affects modulated pathways that are important for tumor development.
Constitutive as well as drug-modulated levels of components of the IGF and HIF-1 pathways were evaluated by western blotting and qPCR.
Establishing mechanism and identifying specific modulated genes and pathways is therefore a priority.
The extent to which these diverse ATF4-modulated pathways might be involved in control of aging rate, longevity, and the development of neoplastic diseases, which are the most typical cause of death in mice, is at this point a matter for speculation and new experimentation.
