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In development, REST function is modulated in multiple ways.
Again, more stringent analysis of genes modulated in multiple conditions and cell types was characterised by an increase in the proportion of observed changes that can be attributed to primary and downstream miR-181b activity.
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Not only is MLC phosphorylation modulated in parallel by multiple kinases, these cell morphodynamic behaviors are controlled by a wide-range of other cytoskeleton processes that are independent of myosin activity.
Several evidences depict that the expressions of miRNAs are remarkably modulated in malignant tissues due to multiple genomic and epigenetic alterations.
Thus, although the design and content features of the IPN model are shared with some previously published inflammation networks, we believe that its cell type-based structure and broad focus on multiple pathways modulated in the CS-exposed lung make the IPN model a unique resource for investigating pulmonary inflammation induced by not only CS, but other complex environmental exposures.
E2F binding to DNA in vivo is modulated by multiple factors in addition to particular motifs.
The TOR pathway modulates ageing in multiple species.
The insulin/insulin-like growth factor (Igf) pathway modulates longevity in multiple species [ 177].
These results also underscore the importance of tight regulation of the IP3 signaling cascade, and demonstrate how IP3 signaling can be modulated at multiple inputs in the pathway.
Therefore, we conclude that stem cell-derived neurons form synaptically connected, excitatory networks, the activity of which can be modulated by multiple neurotransmitters, as occurs in the in vivo cerebral cortex.
Our data reveal that gene regulatory networks modulated by single modulator or co-modulated by multiple modulators play important roles in breast cancer.
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