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For example, a gene that is only regulated under very specific circumstances is unlikely to be modulated in many data sets that are curated in the knowledgebase.
In contrast, a gene whose expression is modulated by a large number of experimental perturbations is likely to be modulated in many data sets that are represented in the knowledgebase, and thus the knowledgebase will likely contain knowledge of many entities that causally regulate the gene.
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ODC activity can also be modulated in response to many signalling pathways including the epidermal growth factor receptor, phospho-inositide 3-kinase (PI3K), and estrogen receptor pathways [ 41- 44].
Indeed, we found in the list of genes modulated in our experiments many mRNAs that has been previously shown to contain target sites for miRNAs [ 43] and thus be post-transcriptionally regulated.
It is known that intracellular CPR expression involved in the activation of bioreductive agents can be modulated in cells by many internal factors such as oxygen deficiency, intracellular pH changes and by malignant transformations themselves (Adams and Stratford, 1994; Forkert et al, 1996).
In all adult tissues examined to date, including the gonads and brain, the expression of many genes is modulated in a sex-specific manner [ 15, 131, 132].
Overall, many ECM-gene transcripts were only modulated in subjects that demonstrated a concurrent improvement in aerobic capacity.
In the past decades, many genes have been found to be modulated in cancer cells.
Also many apolipoproteins (apolipoproteins A-I, A-IV, and E) are modulated in our model supporting this hypothesis.
Many of these genes have been described previously as belonging to other regulons whose expression is modulated in stationary phase.
The ECM modulates repair in many tissues, including the liver.
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