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This RAGE-based PTK profiling allowed us to quickly screen tyrosine-kinase genes modulated in cells treated with various reagents.
In a preliminary study, we found that IL-6 expression is modulated in cells expressing various levels of Id-1.
Phosphorylation at this site therefore provides an additional mechanism through which the specificity of NF-κB transcriptional activity can be modulated in cells.
In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transcription is modulated in cells undergoing a mitogenic response to TPA were isolated by differential screening of a cDNA library from TPA-treated cells.
To address the question of whether es expression could be modulated in cells exposed to drugs which inhibit de novo synthesis of nucleotides, cells were exposed to antimetabolite drugs having different modes of action.
MAPK/ERK might participate in mediating the effect of TNF-α and IGF1 on mature miRNA abundance, as the effect of TNF-α and IGF1 on miRNA expression was modulated in cells treated with MAPK/ERK inhibitor (Additional file 8A-C).
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Further studies are required to define which signaling pathway(s) involved in cell cycle regulation is modulated in cancer cells by expression of NES-hTERT.
Therefore, dissection of the underlying mechanisms of immune activation when NFκB is modulated in the cells might help design strategies to target each disease accordingly.
Light scatter from lysosomes has been modulated in EMT6 cells.
In the past decades, many genes have been found to be modulated in cancer cells.
IL1R1 and APOD levels are slightly modulated in BCAR1 cells, in agreement with the hybridisation data.
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