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The Clinically protected human hosts, including sicklers, are known to get immunity faster than others due to modulated immune response [ 31, 32].
Third, does the modulated immune response translate into benefit at the level of organ function?
In weaned piglets, yeast beta-glucan administration increased serum levels of antibodies and modulated immune response by mitigating the increase of pro-inflammatory cytokines after immunological challenge [ 18].
Recent studies suggest that an active modulated immune response can direct tissue regeneration; inflammatory cytokines have an important role in initiation of acute inflammation, cell proliferation, and modulation of tissue healing.
On the other hand, a modulated immune response to bacteria that colonize epithelial surfaces during the first period of life, including the intestines, is a prerequisite to establish bacterial colonization and concurrently maintain homeostasis [ 39].
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Citri reticulatae pericarpium, and Saposhnikoviae radix, have also been shown to have effective anti-inflammatory activities and modulated immune responses, which may also exert a preventive effect in allergic airway inflammation.
Fig. 1 GM-CSF-modulated immune response to IV infection.
We applied pancancer AMARETTO on eleven cancer sites and idenditifed pancancer driver genes of smoking-induced cancers and 'antiviral' interferon-modulated innate immune response.
In general, the outcomes demonstrated that the use of C. verbenacea was effective against periodontal pathogens; it also positively modulated immune-inflammatory response, minimizing the alveolar bone loss in ligature-induced periodontitis.
In the current investigation we would like to test the hypothesis that the Bz-therapy modulates the immune response inducing a long-lasting impact on the immunological status of treated patients, inducing a similar Type-1 modulated cytokine profile as observed early after the end of the treatment [ 13, 14].
Moreover, this exaggerated and non-modulated type-1 immune response observed in CL and ML is associated with the production of pro-inflammatory cytokines and tissue damage [ 7].
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