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The co-expression network indicates that Rx3 regulates optic vesicle morphogenesis through a complicated and highly modulated gene network.
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To explore interactions within the set of BaP modulated genes, networks were generated in MetaCore using Analyze algorithm with default settings.
b Top three hub genes (and the numbers of their first-order connected genes) in each modulated gene regulatory network.
Computational predictions of the disrupted NOTCH1-dependent gene network revealed regulatory nodes that, when modulated, restored the network toward the NOTCH1+/+ state.
Furthermore, we explored enriched functions in the modulated gene pairs carrying distinct co-modulation patterns.
However, analyses of modulated gene regulation typically focus on how expression levels of modulators affect regulating strength, instead of the causal relationships, between modulated genes.
Gari, E., Piedrafita, L., Aldea, M. & Herrero, E. A set of vectors with a tetracycline-regulatable promoter system for modulated gene expression in Saccharomyces cerevisiae.
Gari E, Piedrafita L, Aldea M, Herrero E. A set of vectors with a tetracycline-regulatable promoter system for modulated gene expression in Saccharomyces cerevisiae.
tPA modulated gene expression related to the immune system.
These 223 genes represent about 13% of the modulated gene set (1700 transcripts).
This could result in modulated gene expression patterns that may contribute to phenotypic variation.
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