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Those effects may be modulated, for example, by rapid detoxification before coming into contact with DNA, or by effective repair of induced DNA lesions.

Calpain activity may be modulated, for example, by phosphoinositide/lipid binding [8], [9] or phosphorylation [10].

Mitochondrial DNA evolution at the population level may be modulated for example by the climatic variables [ 4] or by the diet of individuals [ 29].

The activity in descending pathways is not constant but can be modulated, for example, by the level of vigilance or attention and by stress [ 47].

However, while a relationship between resting functional connectivity and local inhibition has been established in the basal state, it has not yet been shown whether this relationship holds when local inhibition has been modulated, for example, after plasticity induction.

Articulation may be modulated, for example, by visual or auditory rhythmic cues (Pilon et al., 1998; Brendel and Ziegler, 2008) or rhythmic tapping of the left hand, thus engaging sensorimotor networks in the right hemisphere (Gentilucci and Dalla Volta, 2008).

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There is further evidence for the involvement of nAChRs in the control of CNS maturation by modulating, for example, gene expression, cell proliferation, differentiation and apoptosis [ 70].

The effect of regulatory variants depends on the sequences that they modulate (for example, promoter or enhancer elements, or encoded regulatory RNAs) and the functional regulatory epigenomic landscape in which they occur.

Although activation of biosynthetic genes at the transcriptional level is primarily important for exploiting useful metabolites, perturbation of biosynthesis by modulating, for example, the supply of precursors may also be a promising approach to enhancing the cell's capability to produce secondary metabolites, a process termed metabolic engineering (Olano et al. 2008).

This is due to a conceivably greater cerebral area being modulated when for example using an extracephalic reference, which when treating major depressive disorder, may be just as effective (if not more) than a 'bi-cerebral' montage, as it may activate a larger network of brain regions involved in depression.

Proteins specific to individual herpesviruses can modulate fusion, for example the Herpes simplex virus gD brings together gB and gH/gL after ligand engagement to trigger fusion [3], [4], and the Epstein-Barr virus gp42 binds gH/gL to promote B cell over epithelial cell fusion [5].

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