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In animals, many miRNAs with distinct spatio-temporal expression patterns are modulated by transcriptional and/or post-transcription regulation [ 55].
The NF-κB-dependent transcription rate constant of IκBα could be modulated by transcriptional co-factors of NF-κB.
In the light of these results and the PGC-1β control of basal mitochondrial biogenesis, we aimed to determine whether PGC-1β was able to control Mfn2 transcription and, therefore, if the mitochondrial dynamics balance could be modulated by transcriptional regulation.
Fibrotic responses are modulated by transcriptional activators and cofactors, epigenetic factors, and microRNAs that can amplify or inhibit ligand-induced signaling.
Physiological changes elicited by external signals can be modulated by transcriptional regulation leading to the induction or repression of target genes.
The remarkable adaptability of this bacterium is partly modulated by transcriptional regulators that tailor gene expression to the conditions encountered, with a pivotal role being played by sigma factors that target RNA polymerase to specific promoter sequences [ 2].
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In addition, 28 of these fluctuating lincRNAs peaked at ZT14 and ZT22, and thus may modulate or be modulated by the transcriptional or post-transcriptional regulation of protein-coding genes of the twin-peaking synaptic module described earlier.
Chondrogenic differentiation and the SOX9 dependency of aggrecan and collagen expression may also be differentially modulated by these transcriptional cofactors under different tonicities.
These studies imply that FAK expression and its biological functions may be modulated by the transcriptional regulators and its coamplification miR-151.
Our results suggest that the DAP3 gene is modulated by major transcriptional regulators of mitochondrial biogenesis, and coregulated with genes of the small subunit of the mitochondrial ribosome.
Thus, these data suggest that in addition to epigenetic HDAC1-dependent repression of the CerS1 promoter, CerS1 transcription might also be modulated by post-transcriptional mechanisms.
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