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Using the model, we were successfully able to predict how Stat3 activation is modulated by three micro-fabrication parameters: colony size, colony separation, and degree of clustering.
In P. aeruginosa, the output of the Gac/Rsm pathway is modulated by three sensor kinases (Jimenez et al., 2012).
The asymmetric anion binding appears to be modulated by three major factors: anion type, protein conformation and surface electrostatic potential.
The propensity of Ire1 for activation is modulated by three parameters: (1) its local concentration, (2) its phosphorylation state and (3) its interactions with cofactors in the ATP binding site of Ire1's kinase module.
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Also, there were 9 pairs of genes modulated by nine of the ten modulators, including the pair of forkhead box A1 (FOXand and fructose-1,6-bisphosphatase 1 (FBP1).
The 'separate modifiability' criterion requires two different measures (here, two fMRI multivariate patterns) to be separately modulated by two manipulations without cross-influences.
In plant development, the flowering transition and inflorescence architecture are modulated by two homologous proteins, FLOWERING LOCUS T (FT) and TERMINAL FLOWER 1 (TFL1).
The difference in antigen potency is modulated by two cavities in the TCR combining site, formed mainly by CDRs 3alpha, 3beta, and 1beta, that complement centrally located peptide residues.
These results imply that PPI might be modulated by four genotypes – COMT rs4680 (primarily in males), GRIK3 rs1027599, TCF4 rs9960767, and PRODH rs385440 – indicating a role of these gene variations in the development of early information processing deficits in schizophrenia.
Figure 15 The -QAM hierarchical constellation modulated by two sequences of data bits.
It is known that the extracellular glycine concentration is modulated by two glycine transporters (GlyT1 and GlyT2) [3].
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