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Exact(4)
By varying the conditions, signaling pathways or genetic background, one can also assess how the response of the cell or material is modulated by that pathway.
IgCAMs and RTKs (EGFRs in particular) are known to be associated with membrane rafts in a number of systems and the function of RTKs appears to be modulated by that association [29] [39].
However, when designing a specific study, it would be wise to consider the possibility that a particular marker is modulated by that particular nutritional modification (e.g. based on existing data or on mechanistic insights).
Probably the most spectacular demonstration of this phenomenon is the composite face effect (Young, Hellawell, & Hay, 1987) – that is, when a facial image is composed of the bottom and top halves of two different faces, where recognition of one half of a face (e.g., the top part) is modulated by that of the other half (e.g., the bottom part).
Similar(56)
However, as shown in Fig. 1a, it is not implausible that error awareness is modulated by factors that take effect already prior to error-related pMFC activity and may thus influence these early correlates as well (Fig. 1a).
Specificity for and discrimination between target sites, effected primarily by amino acid residues that contact DNA, can be modulated by those that do not interact with DNA or with a DNA-contacting residue.
Although unaffected by p53, we considered that DRAM-3 expression may be modulated by factors that elicit an autophagic or cellular stress response.
This suggested that the O-GlcNAcylation levels on TAB1 are modulated by stimuli that are known to activate TAK1 signalling, and could perhaps also affect signalling downstream of TAK1.
Hence, visual attention seems to be modulated by mechanisms that are separate for valence and arousal.
Activity can be modulated by residues that are distant from the binding site and these interactions within and between functional sites are crucial for protein activity.
The observation that TDP-43 binds TIA-1, co-localizes with SGs and can be modulated by factors that regulate SG biology suggests intriguing questions related to mechanisms of neurodegeneration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com