Furthermore, the dopaminergic neurons of the VTA also show pacemaking activity, but the activity in these neurons is modulated primarily by sodium with minimal contribution from calcium channels (Khaliq and Bean, 2010).
While pain control and epilepsy are still the major focus of interest in terms of sodium channel drug development, it remains possible that indications ranging from autism to immune disorders may be modulated by compounds targeted at sodium channel activity.
The above static scattering data indicate that intermolecular protein interactions are strongly modulated by the concentration of sodium chloride.
Blood pressure is salt-sensitive in the majority of individuals, i.e., modulated by changes in dietary sodium intake.
Release rates of the macromolecules were modulated by the addition of sodium alginate to the TSP channels, increasing from 3 h to 3 days for 80% release.
The release rate of divalproex sodium was modulated by varying different rate‐controlling hydrophilic polymers and measured in vitro using a USP apparatus II dissolution method.
The data are modulated by 16QAM modulation.
Pain is modulated by a subset of the voltage-gated sodium channels, including Nav1.3, Nav1.7, Nav1.8 and Nav1.9.
It has been reported that sodium pumps' activities can be modulated by herbal products, such as Petroselinum hortense extracts, which inhibit (Na+,K+ -ATPase, and saponins isolated from Costus spicatus Swartz, which inhibit Na+-ATPase activity [ 24, 25].
Collectively, results from this study suggest that the excitatory glutamatergic neurons in the hippocampus are modulated by inhibitory GABA-releasing interneurons and that other mechanisms, beside sodium channels, may be involved with the neurotoxic action of pyrethroids.
