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Further research is warranted to investigate whether the impact of Y143C/R on IN functions and on resistance to RAL at the enzymatic level could be modulated by secondary INI resistance mutations.
Although further investigations are required to confirm whether the primary or secondary reward is more important in VTA/SN and NA activations, it is possible that VTA/SN and NA regions could be modulated by secondary rewards, or money.
Since associations between impulsivity and white matter microstructure may be modulated by secondary variables including substance abuse, we included monthly alcohol consumption and smoking as additional covariates in the analyses.
Although the nature of the ligand itself determines primary interaction energies with the heme, and therefore is the primary determinant of the reduction potential, the electronic character of the ligand can be further modulated by secondary noncovalent interactions, such as hydrogen bonds.
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Hence, the affinity of the gp41-lectin site for the galactose harbored by the mucosal HIV-1 receptor GalCer is modulated by the peptide secondary and tertiary structure and the local environment.
Structural comparisons of TRPV1 and TRPV2 indicate that a rotation of the ankyrin-repeat domain is coupled to pore opening via the TRP domain, and this pore opening can be modulated by rearrangements in the secondary structure of S6.
Moreover, the level of resistance was not only linked to the amino acid found in position 143, but was highly modulated by the combination with secondary mutations and also by the back-ground integrase sequence present in patient at baseline [28].
However, another study using a dual-task paradigm (Adam et al., 2008) found evidence for a foveal bias in perceived location that was modulated by the difficulty of the secondary task at fixation.
These findings suggest that NA responses could not be modulated by the difference of primary and secondary rewards.
−1 PRFs signals are typically characterized by a 'slippery' sequence (X XXY YYZ) that is modulated by the presence of a downstream secondary structure, most commonly a pseudoknot (Plant et al., 2003; Jacobs et al., 2007; Caliskan et al., 2014; Chen et al., 2014; Kim et al., 2014).
The data are modulated by 16QAM modulation.
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