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Further, M current generated by opening of KCNQ channels has been modulated by reactive oxygen/nitrogen species.
Although the relative contribution of furan mediated alterations in metabolic pathways and antioxidant defense to the overall toxic response to furan, including considerations of dose and time, remains to be established, our work contributes to mapping biological processes and toxicity pathways modulated by reactive electrophiles.
Our recent in vitro work demonstrated that swelling activated excitatory amino acid release via VRAC is potently modulated by reactive nitrogen species and reactive oxygen species [68], [69].
The "mitochondrial theory of aging" stipulates that the aging process is modulated by reactive oxygen species (ROS -mediated toxicity leading to mitochondROS -mediatedNA) deletoxicityd mutations, macromoleading oxidatoon, electron transport chain (ETC) dysfunction, cellular senescence and cell death [28]–[30].
BKCa are also modulated by reactive oxidative species (ROS), which can activate or inactivate BKCa [ 13].
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If the iron-sulfur cluster in Rtel1 is as sensitive to hydrogen peroxide or nitric oxide as that in RtelN, the DNA helicase activity of Rtel1 could be modulated by intracellular reactive oxygen/nitrogen species.
The importance of an inflammatory microenvironment is so strong that even the time frame within which an oncogene-addicted cell population gives rise to a tumor in transgenic mice is modulated by the reactive stroma that surrounds the cancer lesion [ 9].
Moreover, this network responds to the age-related partial mitochondrial dysfunction and is modulated by mitochondrially produced reactive oxygen species (ROS) [ 3, 8, 10, 11].
It was found that the content of the phospholipid moieties on the membrane surface, which can be mainly modulated by the content of reactive hydroxyl groups in PANCHEMA, has a great influence on the performances of the studied membranes.
We also show that this sensitization is through a novel pathway modulated by Bmi-1, namely reactive oxygen species (ROS) induction causing engagement of the DNA damage response (DDR) pathway leading to apoptosis.
Fibrosis is a reactive process modulated by various factors propagated by an inflammatory tissue reaction.
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