Sentence examples for modulated by posttranslational from inspiring English sources
These proteins roam the nucleus, perhaps as part of multiprotein complexes, and their target interactions are modulated by posttranslational modifications.
The functions of ECM glycoproteins are modulated by posttranslational modifications, such as glycosylation, phosphorylation and sulfation.
The binding of MOZ/MORF complexes to specific genomic regions and their activity are modulated by posttranslational histone modifications.
Moreover, GR-mediated transcriptional regulation can be modulated by posttranslational modifications or by concurrent expression of dominant negative splice variants and other isoforms.
In addition the transfer of Ca2+ across the IMM appears to be modulated by posttranslational modifications, such as phosphorylation [12,13], small diffusible messengers such as nucleotides [14] or polyamines [15], the proton concentration within the matrix of mitochondria [16] and Ca2+ itself [17,18], which all are thought to affect the activity of mitochondrial Ca2+ channels in intact cells.
The TGF- β/Smad pathway is modulated by several posttranslational modifications, including phosphorylation, ubiquitination, and acetylation [ 7, 8].
The stabilities of p63 proteins are modulated by diverse posttranslational modification, such as phosphorylation, ubiquitylation, SUMOylation, and ISGylation, in which various proteins are involved [ 26, 37– 37].
The emerging paradigm is that distinct aspects of Hsp90 function are modulated by a posttranslational code defined by a multitude of regulators and target residues.
In addition, the rs763361 glycine to serine substitution could interfere in the phosphorylation of CD226 at 322Tyr and 329Ser residues, and the downstream signaling pathway may be modulated by these posttranslational modifications [ 16, 22].
It has been proposed that the function of microtubules is modulated by highly diverse posttranslational modifications of tubulin dimers [ 5].
The activity of a signaling pathway can be modulated either by posttranslational modification, or regulation of expression of a pathway member.
