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The redox potential of the T1 center was strongly modulated by physiological factors including pH, anaerobic and aerobic conditions and the presence of inhibitors.
The rate and selectivity of the proteasome-mediated protein degradation by the N-end rule pathway are modulated by physiological effectors, including specific phosphokinases, short peptides, redox, heme and nitric oxide (see Introduction).
Extensive studies on adult hippocampal neurogenesis have revealed that it can be modulated by physiological and behavioural events, such as aging, stress, disease, seizures and learning.
AChE levels are regulated at transcriptional, post-transcriptional and post-translational levels, leading to complex expression patterns which are modulated by physiological and pathological conditions through mechanisms that are not fully understood.
Since plant defense signaling mechanisms may well be selected to respond as rapidly as possible to the presence of herbivores, their initial response is probably modulated by physiological means in the first instance, rather than by changes in expression levels.
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In addition, this binomial peripheral crosstalk is modulated by several physiological factors which include both peripheral neuroendocrine and central nervous system (CNS) mechanisms.
This analysis suggests that there is at least some overlap between genes modulated by known physiological stressors in D. melanogaster and by the presence/absence of glucosinolates in larval host plants of S. flava.
As we mentioned previously, the biochemical phenotype of an organism is the final result of interactions between the genotype and the environmental stimuli; but it is also modulated by intracellular physiological fluctuations that are part of homeostasis [ 3].
In one of these, the effect of rapamycin on the polysomal distribution of mRNAs was demonstrated to be coupled to the activity of AKT [ 7], a result that demonstrates the extent to which a drugs effect can be modulated by the physiological status of the cell.
In addition to the role of PAI-1 in coagulation, it is responsible for development of lung injury/fibrosis; its expression is also modulated by other physiological stimuli such as hypoxia, transforming growth factor-β (TGF-β) and lipopolysaccharide (LPS) [ 18– 20].
On the other hand, the commensal bacteria in the colon, the gut microbiota, can be differently modulated by diet or physiological conditions of the gut and can consequently influence the gut immune system [16].
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modulated by psychological
modulated by noradrenergic
modulated by extracellular
modulated by cytokine
modulated by free
modulated by retinoic
modulated by motivational
modulated by multiple
modulated by autonomic
modulated by external
modulated by glucocorticoid
modulated by multi-site
modulated by post-translational
modulated by exogenous
modulated by several
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