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Interestingly, 36 (out of 45, 80.00%) pairs of modulators showed significant positive co-occurrence (Fisher's exact two-tailed p-value < 0.05); i.e., gene pairs modulated by one modulator tended to be also modulated by another modulator.
To understand the joint effects of the 10 candidate modulators, we analyzed pairwise co-occurrence as significant modulators among the genome-wide gene pairs; i.e., we statistically inferred whether gene pairs modulated by one modulator gene are highly overlapped with those modulated by another modulator.
In a recent linkage analysis of genome-wide gene-expression patterns in lymphoblastoid lines, the gene encoding the leukocyte-derived arginine aminopeptidase (LRAP) was identified as having its expression levels modulated by one of the most pronounced effects in cis, mapping to a single-nucleotide polymorphism (rs2762).
T(E) is shown for: (a) a uniform straight wire 10 nm thick (black) and of a wire modulated by one dot (red), (b) a wire modulated by one dot (red) and by three dots (blue).
Figure 6 ZT 0 versus E F, at T = 10 K, for nanowires modulated by one dot (red), three dots (blue) and five dots (dark green).
If the clock of the backscattering tag does not synchronize with the clock of the reader, such modulation incurs mismatch, that is, the front part of a channel response received at the tag may be modulated by one bit while the tail is modulated by the next data bit.
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Given the multiplicity of molecules modulated by HIPK2, one cannot assume that only one pathway might be involved.
Filled circles with just one value > 1 represent cells significantly modulated by only one of the two tasks.
Treatment with diphenylene iodonium chloride (DPI, an inhibitor of NOX) can rescue the attachment of rat aortic smooth muscle cells to laminin-111.27 Two sites on integrin α7 have been identified to be modulated by H2O2, one being located in the genu region and another in the calf 2 domain.
ESR1− ERBB2 co-modulation was the largest group modulated by more than one modulators.
Ten major clusters were generated using the hierarchical clustering method done by the software Genesis [ 27] on the probesets whose expression profiles were modulated by at least one of the factors.
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