Sentence examples for modulated by mutations from inspiring English sources

It has also been shown that the propensity of ApoAI to form fibrils is modulated by mutations and oxidation.

P450s may be especially prone to this type of change, since their catalytic mechanism involves large substrate-induced conformational shifts [ 40] that can be modulated by mutations distant from the active site [ 32, 37, 41].

Therefore, we propose the magnitude of the TM7−TM2 interaction as a property modulated by mutations at positions 7.53 and 7.60 that contributes to the final receptor phenotype, in combination with the TM7−HX8 conformational sampling.

Translation efficiency is also targeted by PI3K signaling and modulated by mutation in tumor suppressors PTEN and TSC.

The efficiency of transcription of the pac gene can be genetically modulated by mutation or removal of the regulatory region, mutations in the transcription initiation region, or by replacement of the pac promoter [ 9- 11].

The nuclease activity can be modulated by mutation of the ATP-binding cleft of the helicase domain, and is inhibited by ATP or ADP, suggesting a modified role for the inactive helicase domain in the control of the nuclease activity.

The exonuclease activity is modulated by mutation of the helicase ATP-binding cleft and by ATP or ADP binding, suggesting a modified role for the helicase domain in the regulation of nuclease activity in these enzymes.

Of these two hypotheses, the gene cluster model seemed to most faithfully represent Ohno's postulate that the major mechanisms behind genomic evolution are gene duplication, modulated by mutation, insertion and deletion [ 1].

The aim of this article is to derive explicit analytic expressions for the fixation process of genes whose fitness is modulated by phenotypic mutations, and to show that adaptive phenotypic mutations can undergo positive selection under biologically plausible conditions.

Similarly, sulfadoxine (SD) resistance is conferred by a key mutation at codon 437 in the pfdhps gene and modulated by additional mutations at codons 436, 540, 581, and 613 [ 22].

20, 21 In the presence of pfcrt 76T, chloroquine resistance is modulated by point mutations in the gene that encodes the P. falciparum multidrug resistance transporter 1 (primarilyprimatily at codon 86 23, 23 and also by mutations at positions 184, 1034, 1042, and 1246.