While the former can be modulated by modification, as discussed previously, the latter can be controlled by scaffolding or by altering the expression level, stability or subcellular localization of the competing binding partners (3).
Whether the C H amination reactivity of the catalysts described here can be further enhanced and modulated by modification of the heme environment remains an open question which will be addressed in the future.
Here we propose that co-transcriptional recruitment of splicing factor is modulated by histone modifications and Pol II processivity, which provides a link between chromatin modifications, transcription and splicing.
These proteins roam the nucleus, perhaps as part of multiprotein complexes, and their target interactions are modulated by posttranslational modifications.
However, what is the molecular basis for the tethering activity of SMC complexes and how this activity is modulated by regulatory modifications of the complex or auxillary factors remain unanswered.
We bring out the rotation induced complex flow dynamics during the transience, leading to possible augmentations in mixing, as modulated by the modifications in the force distribution in the flow-field.
Transcriptional regulation of genes is modulated by histone modifications, DNA methylation, and non-coding RNA binding [18].
However, at variance with ERAD substrates and bacterial toxins, we propose that CRT retrotranslocation is modulated by structural modifications triggered by variations of ER calcium levels.
The biological activity and cellular distribution of a given protein is often modulated by covalent modifications of amino acid side chains.
The functions of ECM glycoproteins are modulated by posttranslational modifications, such as glycosylation, phosphorylation and sulfation.
