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Whether the C H amination reactivity of the catalysts described here can be further enhanced and modulated by modification of the heme environment remains an open question which will be addressed in the future.
While the former can be modulated by modification, as discussed previously, the latter can be controlled by scaffolding or by altering the expression level, stability or subcellular localization of the competing binding partners (3).
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The absence of N-response in G2 after HP1 overexpression suggests that N-responsiveness is modulated by modifications in the chromatin structure.
Catalytic activities are modulated by component modification and system parameters and are often dependent upon driving forces for intramolecular electron transfer, reductive excited state quenching, and component modification.
Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated.
Existing data supporting the role of nanotopography suggest that critical steps in osseointegration can be modulated by nanoscale modification of the implant surface.
The stability of cell patterns could be modulated by simply modification of the surface chemistry of base substrate and PEM films with conjugation of bioactive macromolecules.
The action of antifungal agents is modulated by subtle modification of the membrane lipid composition [17].
Third, immunogenicity can be easily modulated by chemical modification.
Tyrosine phosphorylation has also been implicated in mitochondrial regulation, in which the energy production system of a cell is modulated by the modification of mitochondrial proteins [ 4].
Despite the importance of post-translational modifications in controlling the solubility and conformational properties of proteins and peptides, precisely how the aggregation propensity of different peptide sequences is modulated by chemical modification remains unclear.
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