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A novel (to our knowledge) aspect of our results is that receptor dimerization is modulated by membrane cholesterol.
The β2-adrenergic receptor is an important member of the G-protein-coupled receptor (GPCR) superfamily, whose stability and function are modulated by membrane cholesterol.
The interaction of V122I TTR with the cells appears to depend on membrane protein(s) and is modulated by membrane cholesterol.
In podocytes, this dynamic regulation is mainly modulated by membrane proteins that are located in the glomerular basement membrane and slit diaphragm areas [ 5].
Subsequently, much attention was paid to the TRP channel family, given their established roles in Drosophila mechanotransduction and reports that some mammalian TRP channels are modulated by membrane stretch (Christensen and Corey, 2007).
Furthermore, gating of RyR is modulated by membrane potential with steps to hyperpolarized or depolarized potentials of more than ∼40 mV causing an initial activation and then inactivation (191).
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Equally, it is possible that GBF1 sensitivity to BFA is modulated by its membrane receptors, and the membrane recruitment of GBF1 at the ER-Golgi route is more sensitive to BFA than membrane recruitment at the plasma membrane.
Plasma membrane tension is controlled mainly by the surface area of the membrane relative to cell volume and can be modulated by changing membrane composition, shape and the organization of membrane-associated proteins.
Furthermore Cm was modulated by the membrane potential and the external proton concentration.
In addition to sucrose Cm was modulated by the membrane potential and external protons.
After blocking inhibition, Hausselt et al. [13] found that directional signals in SBACs were modulated by SBAC membrane potential, and suggested a role for a voltage-dependant non-linearity.
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