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The efficiency of the placenta as a barrier against the passage of Cd might be modulated by maternal polymorphisms in genes that code for metal-binding metallothionein protein (Tekin et al. 2011a).
However, if Cd levels in the placenta, as well as the placenta's efficacy as a barrier, are modulated by maternal polymorphisms linked to metallothionein, this information should be considered in the assessment of this biomarker in terms of exposure.
Fetal growth is characterized by its genetically predetermined growth potential; however, it is further modulated by maternal, fetal, placental, and environmental factors [ 1, 2].
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Transgenerational effects of alcohol (as well as of nutritional supplements and endocrine disrupters) must, of necessity, be mediated through the process of gametogenesis and can be modulated by the maternal environment during pregnancy.
Furthermore, as shown for body weight regulation and obesity but might also apply to other endocrine axes, the set points for endocrine axes are modulated by the maternal "environment" of the fetus (Plagemann 2005); this process could be disturbed by the influence of EDCs.
These findings support the view that differences in the neonatal environment can have profound life-long impact on social and HPA function and that this impact is modulated by differences in maternal care reliability.
We have recently shown in both non-human primates and in rodents that fetal and neonatal hepatic expression of the circadian transcription factor, Npas2, is modulated by a high fat maternal diet and plays a critical role in establishing life-long metabolic homeostasis.
These growth changes may be a result of embryonic and organ energy substrate preference, which are modulated by their concentration in maternal circulation, as well as their transport across the placenta at the various gestational time-points.
The data are modulated by 16QAM modulation.
In this regard, recently, our group demonstrated the increased risk association between maternal smoking and EAL with MLL-r modulated by genetic susceptibility [ 44].
Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism.
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