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Higher-level processing difficulty was modulated by manipulating lexical status (words vs. word-like pseudowords).
Low-level processing difficulty was modulated by manipulating letter-rotation parametrically at 0°, 22.5°, 45°, 67.5°, and 90°.
Furthermore, Moles and D'Amato [79] have shown that social investigation and the number of ultrasonic calls can be modulated by manipulating the attractiveness of the test partner.
The visibility of targets in dot-view stimuli can be modulated by manipulating the ratio of signal to noise pixels (see Figure 1B, Figure 1C, Movie S1 and Movie S2).
Recombination hotspots in mice also occur in nongenic regions, and the distributions of recombination hotspots can be modulated by manipulating PRDM9 sequences (Brick et al. 2012).
When progenitor cells are grown in 3D, stemness can be modulated by manipulating the growth factors they are exposed to and direct differentiation towards a desired linage.
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We envision that 'controller cells' that modulate bacterial behavior by manipulating molecular communication, will find use in a variety of applications, particularly those employing natural or synthetic bacterial consortia.
If StC were entirely passive during this process, it should be impossible to modulate this process, by manipulating gene expression in the soma, except if the genes encoded for direct cell shape regulators, such as Myosin, Actin, adhesion molecules etc.
Furthermore, to explore the possibility of modulating gene expression by manipulating the epigenetic state of a gene, we and others have fused DNA methyltransferase domains to synthetic zinc finger proteins to direct methylation to specific DNA sequences.
In addition, a study on cancer cachexia found that the activity of triglyceride-fatty acid substrate cycle was elevated in tumors of murine white adipose tissue due to differential expression of the cycle enzymes [ 27], which sets up an intriguing possibility of modulating tumor growth by manipulating these enzymes.
It is likely that these release and inhibition periods could be extended or modulated in future studies by manipulating peptide loading levels or other variables such as the thickness, porosity, or degree of chemical functionalization of the coatings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com