Kim, K. M., Nakajima, Y. & Nakajima, S. G protein-coupled inward rectifier modulated by dopamine agonists in cultured substantia nigra neurons.
Under normal physiological conditions the motor output (gain) can be modulated by activation of channels in the motor neurons that conduct persistent inward currents, resulting in plateau potentials and sustained firing, leading to enhanced and prolonged muscle contraction [ 9- 14].
The data are modulated by 16QAM modulation.
Both PV and SOM interneurons are modulated by various neurotransmitters1 and in particular SOM interneurons are strongly modulated by acetylcholine8,9,10,11,12,13.
Ventral OLMα2 cells are strongly modulated by cholinergic inputs39, and changes in cholinergic drive might also modulate theta2 frequency.
One class of ion channel that is potentially modulated by cGMP is the hyperpolarization-activated cyclic nucleotide-modulated cation (HCN) channel, which generates an inward current [termed hyperpolarization-activated current (Ih)] at membrane potentials negative to approximately −50 mV.
The spectra of galactic cosmic rays observed anywhere inside the heliosphere are modulated by the sun because the charged particles must fight their ways inward against the radially expanding solar wind.
As an example, we show the current and conductance changes for a slowly inactivating A-type K + channel (Kv1.2, I As), L-type calcium channel (I CaL) and inward rectifying K + channel (I Kir) at different membrane potentials modulated by a scaling factor µ = {0.6, 0.8, 1.0, 1.4} 1.4}.
In other words, it is a switch modulated by light.
Modelled AP half-width was modulated by the strength of the current injection for neurons with low (that is, immature), but not high (that is, mature) Na+/K+ conductances, suggesting a strong inward current after stimulation.
