Sentence examples for modulated by hypoxia from inspiring English sources

Botlagunta, M. et al. Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells.

This will allow us to gain a better understanding of the protein repertoire that is modulated by hypoxia during breast tumorigenesis.

In the literature, it has been demonstrated that expression of the ATF4 protein (PERK pathway) could be modulated by hypoxia.

This signature is composed by 11 probesets representing 8 well characterized genes known to be modulated by hypoxia.

For example, AK3L1 is known to be modulated by hypoxia and catalyzes the interconversion of adenine nucleotides playing an important role in cellular energy homeostasis in mitochondria [ 47].

IL8 is secreted by a large number of tumors, including breast [ 30], and its expression is reported to be modulated by hypoxia [ 31- 33].

Studies have shown that GLUT1 is modulated by hypoxia-responsive elements and upregulated by overexpression of HIF-1 [51].

Besides mitochondrial damage, the inflammatory actions of oxygen are importantly modulated by hypoxia-inducible factor (HIF) [ 15, 16].

As it was shown that Sp1 activity can be modulated by hypoxia-induced phosphorylation or by interaction with HIF-1 α and that hypoxia results in an increase in DNA-methylation potential, we propose that the collective regulation of folate-metabolism genes could be attributed, at least in part, to alterations in Sp1 activity or promoter methylation of these genes.

Recently, two transcriptomic studies of hypoxia compared the action of low oxygen with that of metal ions such as cobalt or nickel on embryonic mouse fibrobasts [ 28] and human liver carcinoma [ 29]. 21% and 28% of the genes respectively were found to be modulated by both hypoxia and cobalt.

It is recognised that PHD2 and PHD3 expression is modulated by directly by hypoxia, but less appreciated is that PHD1 levels may be altered through suppression of its mRNA under hypoxia [ 29].