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To identify potential GR primary target genes in adipocytes, we performed microarray analyses to isolate genes whose expression is modulated by glucocorticoids upon 6-hour-DEX treatment in 3T3-L1 adipocytes.
21 22 AnxA1 is highly abundant in myeloid and stromal cells and its expression can be modulated by glucocorticoids and other anti-inflammatory drugs.
Because of the known role of MARCH1 on HLA-DR trafficking [ 24, 25], we investigated whether MARCH1 was modulated by glucocorticoids.
Oxidative stress, which seems to play an important role in the development of endothelial dysfunction [ 23], is another parameter that was shown to be modulated by glucocorticoids [ 50].
This study has identified regulatory gene networks that are stress activated, and may be modulated by glucocorticoids in leukocytes, and provides a mechanistic framework to characterise the multifaceted nature of weaning stress adaptation in beef calves.
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The biological effect of glucocorticoids is modulated by glucocorticoid receptors.
Endogenous glucocorticoid action within cells and tissues is modulated by intracellular glucocorticoid metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD), which interconvert active glucocorticoids (cortisol, corticosterone) and intrinsically inert 11-keto metabolites (cortisone, 11-dehydrocorticosterone) (4).
This peripheral rhythm of fibroblasts can be modulated by systemic factors, such as glucocorticoids [ 16].
In particular, NF-κB is a target modulated by many iNOS inhibitors such as glucocorticoids and antioxidants [ 11].
Transport of glucocorticoids can be modulated by a changing ratio of cortisol and corticosterone, with evidence of saturable transport in the hypothalamus and pituitary gland.
Endogenous glucocorticoid action is modulated by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD).
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