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This analysis revealed that this operational unit is not simply a homogenous synctium, but has a complex functional organization that is dynamically modulated by extracellular signals such as angiotensin II.
Kir2.3 channels are modulated by extracellular pH [16] [18].
The bacterial Nav channels are modulated by extracellular alkaline pH (pHo).
Intracellular pathways modulated by extracellular glucose involve PKC, MAP kinases, and glucokinase.
ABC transporter activity and/or expression levels may be modulated by extracellular stimuli.
Syk expression and activation are also modulated by extracellular matrix, through integrin signalling (Zhang et al, 2009).
Similar(43)
Through the interaction of heparan sulfate (HS) with both activating FGF polypeptides and transmembrane FGF receptor (FGFR) tyrosine kinases, the system is rigorously modulated by the extracellular matrix and tissue architecture.
Accelerated Mesenchymal Stem Cells (MSCs) condensation and robust MSC-matrix and MSC-MSC interactions on nano-surfaces may provide critical factors contributing to such events, likely through the orchestrated signal cascades and cellular events modulated by the extracellular matrix.
These results are consistent with Wnt-ligand dependent growth of these cells ("autocrine Wnt signaling"), which is modulated by the extracellular Sulfs.
Robust activation of the pathway is required to initiate expression of Wnt target genes [8], [9], but similar to other pathways [47], [48], [49], [50], transcriptional activity of the pathway can be positively or negatively modulated by various extracellular, cytosolic and/or nuclear proteins [5], [6], [10], [26], [28], [30], [31], [32], [33], [35], [36], [51].
These findings support our hypothesis and indicate that LM1-dependent functional differentiation is modulated by the extracellular elasticity.
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