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This would predict that the response of tremor to dopaminergic therapy is modulated by disease duration.
Susceptibility alleles might exert tissue-dependent effects on gene expression, which are possibly modulated by disease type and medical treatment [ 20, 21].
It is remarkable to find such an association in a cross-sectional study because BAFF level could have been modulated by disease activity and perhaps by treatment.
This is because it is able to indirectly measure complex transgenomic co-metabolic interactions that are vital for human health, and which are often modulated by disease [ 49, 50].
In this preliminary investigation of the inflammatory genomics of JRA, we report the application of a novel bioinformatics approach to microarray data for the identification of genes whose expression behavior is modulated by disease in a complex manner at the population level.
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We reasoned that testing of the overlap between these upregulated genes and GWAS risk loci for inflammatory disease would identify genes of importance for intestinal immune homeostasis potentially subject to transcriptional regulation modulated by disease-associated genetic variation.
These m/ z species represent peptides and proteins with expressions that are significantly modulated by the disease.
A functional connectivity analysis examined whether the interaction between the RIFG and striatum was modulated by the disease and/or atomoxetine.
The small overlap between the two microarray signatures confirmed the necessity to consider more data coming from the same measuring technique and also different kind of data in order to incorporate all the genes that are significantly modulated by the disease.
The association of age with long-term mortality risk could be modulated by other diseases and the severity of the acute illness.
Alpha-synuclein concentrations may also be modulated by certain disease-modifying agents in development and so may represent a measure of their efficacy.
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