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This mechanical response is modulated by calcium ions at both low and high force, switching from a stiff, rod-like to a soft, spring-like behavior upon removal of ions.
Ann5 is involved in pollen grain development, germination and pollen tube growth through the promotion of endo-membrane trafficking modulated by calcium (Zhu et al. 2014).
Interestingly, CRT association in vitro with ERp57 and PDI is modulated by calcium.
Also the affinity of the cGMP-gated channel to cGMP is modulated by calcium [7], [28], but this effect seems to be negligible in mammalian rods [29].
The activity of heparin can be modulated by calcium ions (Rabenstein et al. 1995).
34 ROS generation has been shown to be modulated by calcium.
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In 2015, Rattanakul and Lenbury [2] proposed a stochastic Cellular Automata (CA) model of the signal transduction pathway modulated by the calcium sensing (CaS) receptors in order to study how different fractions of healthy (functional) and defective receptors modulate serum calcium concentration.
These effects could be modulated by intracellular calcium concentrations.
This finding was suggestive that the guanylate cyclase activity of the protein is modulated by a calcium-specific rather than an ion-specific effect.
All NFATs share a similar DNA-binding domain, and are modulated by calcineurin, a calcium, calmodulin-dependent serine/threonine protein phosphatase, consisting of a catalytic subunit calcineurin A (CnA), and a tightly associated Ca2+-binding subunit, calcineurin B (CnB) [ 25].
Because colchicine is very effective in inhibiting a variety of MSU-induced neutrophil effector functions, some of which are modulated by MICL, including calcium mobilization and tyrosine phosphorylation, the effect of this anti-inflammatory drug on the MSU-induced internalization of MICL was examined.
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