Sentence examples for modulated by acetylation from inspiring English sources

The transcriptional activity of Sp1 family members can be modulated by acetylation [13], [51], [52] and both Sp1 and Sp3 can interact with HDAC [53], suggesting a role for Sp1 and/or Sp3 acetylation in the Sp1/Sp3-dependent, HDACi-regulated TNFSF9 induction.

The activity and function of Foxo3a and p53 are strongly modulated by acetylation [ 51, 88, 95].

It is important to note that the activity of STAT3 can be post-translationally modulated by acetylation and phosphorylation, and both processes are affected by HDAC inhibitors.

The ability of DGCR8 to bind RNA has been reported to be modulated by acetylation of lysine residues within its dsRBDs (Wada et al., 2012).

In another example contrasting with the predominant view of HDACs' being transcriptional repressors, it was shown that HDAC1 served as a coactivator for the glucocorticoid receptor (GR) and that this function was dynamically modulated by acetylation of HDAC1 itself [ 87].

In this work, we have shown that amebic virulence is possibly modulated by acetylation status and also that Aspirin, which induces actin acetylation, alters the cytoskeleton structuration and function.

PARP-1 activity can be modulated by its acetylation level [ 37, 39], and therefore, we explored the acetylation of PARP-1, as a potential mechanism that would explain the decline in PARP-1 activity in skeletal muscle from young mice.

The DNA damage response, for example, is modulated by the acetylation status of histone and non-histone proteins, and by the opposing activities of histone acetyltransferase and histone deacetylase (HDAC) enzymes.

Activation of MAPK and NFκB signalling pathways, leading to transcriptional activation of NFκB and AP-1, are required for IL-1β-induced IL-6 production, and can be modulated by reversible acetylation.

Also the catalase expression was modulated by the acetylation of histone H4 in leukemia cells, indicating that the regulation of catalase expression is a complex and elusive mechanism involving at least three pathways (Lee et al. 2012).

Previous studies have demonstrated that p53 is also modulated by reversible acetylation, which is inverse to ubiquitylation (Li et al, 2002) because the two post-translational modifications occur at similar lysine residues within p53.