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It was suggested these might be used as molecular tools to modulate virulence in bacteria [36].
This observation indicates that differential pathogenic mechanisms could modulate virulence in disparate vertebrate hosts.
Strategies include engineering VSV surface protein to bind tumor antigens and including transgenes or manipulating the viral genome to modulate virulence in neuronal cells.
The work reported here takes a step toward addressing several of these challenges through the use of novel nonwetting surface coatings to promote the extended, long-term release of macrocyclic peptide-based QSIs that modulate virulence in Staphylococcus aureus, a notorious Gram-positive human pathogen.
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Genetic factors other than serotype may modulate virulence potential in CC199.
Taken together, these data indicate that genetic factors, other than capsule polysaccharide, modulate virulence potential in CC199.
Similarly, Bodini and coworkers found that garlic extract and p-coumaric acid inhibited quorum sensing in quorum sensing reporter strains, indicating that plant compounds potentially modulate virulence by affecting quorum sensing in microbes.
In EPEC, the ribosome-binding GTPase BipA has been shown to modulate virulence expression by increasing LEE transcription, since several key proteins encoded by LEE had lower levels in the absence of BipA.
Ethanolamine can act as a signal to modulate virulence.
META1 has long been associated with virulence but its activity and the processes it influences to modulate virulence have remained unknown.
The mechanisms by which iron modulates virulence gene expression in trichomonads are poorly understood.
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