Sentence examples for modulate tumour cell from inspiring English sources

In fact, several adhesion molecules, cytokines, growth factors and proteases have been identified as downstream targets of PAR1 and have been shown to modulate tumour cell metastasis [ 64].

A number of gene products with anti-apoptotic potential is known to modulate tumour cell viability and resistance to programmed cell death (Thompson, 1995; Chao and Korsmeyer, 1998; Fadeel et al, 2000).

The aim of this study was to investigate directly the effects of tumour-associated TNC-16 and TNC-14/16 TNC-14/16on breast cancer cell behavisoforms tondetermine whether these isoforms modulate tumour cell breastour through regulation of MMP.

Activated stromal fibroblasts, or myofibroblasts, produce matrix constituents that alter the physical structure of the developing cancer 'organ' and also modulate tumour cell behaviour through direct binding interactions with surface receptors (Vonlaufen et al, 2008).

Therefore, morphine by itself does not modulate tumour cell growth in culture but, due to upregulation of COX-2 in tumour cells, stimulates angiogenesis in vivo, resulting in increased tumour growth and metastasis.

The aim of the present study was to investigate if NO is able to modulate tumour cell invasiveness of human colorectal adenocarcinoma cell lines (HRT-18 and HT-29), and whether NO can be induced by cytokines produced by stromal macrophages.

These in vitro results were concordant with clinicopathologic data and support the hypothesis that GNG7 modulates tumour cell invasiveness.

The observed chemotactic potential of tumour cell conditioned media in our study could serve as a model for further research on modulating tumour cell induced monocyte migration.

These results suggest that EGF counteracts E-cadherin-mediated junctional assembly through phosphorylation of beta-catenin and modulates tumour cell behaviour to a more aggressive phenotype.

The death ligands and receptors of the TNF/TNFR family have emerged as attractive candidates for modulating tumour cell apoptosis based on their ability to bypass p53-dependent mechanisms in executing programmed cell death [ 19].

This indicates that the 'constitutively active' Wnt signalling caused by APC/CTNNB1 mutations is actually still modulated by tumour cell intrinsic and/or extrinsic factors (Fodde and Brabletz, 2007).