Sentence examples for modulate tumour behaviour from inspiring English sources

Chemokines have also been shown to modulate tumour behaviour, and the sex-specific effect of the chemokine polymorphisms on the host susceptibility to several diseases has been reported (Liou et al. 2008).

There are already many known inducers of TM expression (Hanly et al, 2005) and by understanding the role of TM in adenocarcinomas, these inducers may provide future potential therapies to modulate tumour behaviour and decrease metastases.

The aim of this study was to investigate directly the effects of tumour-associated TNC-16 and TNC-14/16 TNC-14/16on breast cancer cell behavisoforms tondetermine whether these isoforms modulate tumour cell breastour through regulation of MMP.

Activated stromal fibroblasts, or myofibroblasts, produce matrix constituents that alter the physical structure of the developing cancer 'organ' and also modulate tumour cell behaviour through direct binding interactions with surface receptors (Vonlaufen et al, 2008).

These results suggest that EGF counteracts E-cadherin-mediated junctional assembly through phosphorylation of beta-catenin and modulates tumour cell behaviour to a more aggressive phenotype.

Tumour microenvironment is a fundamental aspect of tumour behaviour, modulating important events as cancer cell migration and invasion, as well as angiogenesis and metastisation.

As FIH-1 is able to modulate HIF-1α activity, it would be expected to affect tumour behaviour in a similar manner.

Our previous findings indicate that hypoxic conditions may modulate the tumour stroma in such a way that a more aggressive tumour behaviour is facilitated, ultimately leading to decreased patient survival.

In the past two decades, the tumour microenvironment has also emerged as an equally important determinant of tumour behaviour (Joyce and Pollard, 2009; McAllister and Weinberg, 2014).

Also, MT gene expression alterations are associated with carcinogenesis and with aggressive tumour behaviour and even chemotherapy resistance11.

In some instances, tumour cells and cells in the tumour stroma cooperate or compete with one another, resulting in complex tumour behaviour.