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Stimulation-mediated sympathetic- and catecholamine-driven effects and variations in the amount of epineurial connective tissue may modulate treatment response [47].
However, the C825T polymorphism in the gene coding for the G protein β3 subunit (GNB3) has been shown to modulate treatment response to triptans[27].
Recent advances in pharmacogenetics and pharmacogenomics have identified several host genetic determinants that modulate treatment response and toxicity with these drugs.
Few studies have considered the influence of life-time estrogen exposure which may have an independent effect on cognition and/or modulate treatment response.
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However, the impact of individual epigenetic modifications on modulating treatment response to antidepressants is a neglected field so far.
This suggested a role for CYCLON as a key MYC effector in modulating treatment response, in particular to Rituximab, at least in BL and DLBCL of the GCB subtype.
Our results provide evidence that the unfavorable prognosis of MB patients with high c-MYC expressing tumors may not be explicable by their poor response to treatment, although additional validations in xenografts and a larger MB cohort is necessary to clarify the exact role of c-MYC in modulating treatment response.
The latter has been shown to modulate the treatment response to temozolomide [ 23].
Among factors that have been shown to modulate antidepressant treatment response in major depression are disease severity, longer duration and frequency of the episodes, comorbid anxiety disorders, and an older age of onset [ 7].
Adiponectin, but not leptin, is associated with pain severity and is modulated by treatment response in episodic migraineurs.
Such changes in the glycosylation of cell-surface proteins influence tumour microenvironment and immune responses that may modulate treatment outcome and the course of disease.
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