Sentence examples for modulate transgene expression from inspiring English sources

In general terms, the method allows to modulate transgene expression at the post-transcriptional level.

Thus, lentiviral-derived ectopic expression of ligands can modulate transgene expression in the epithelium.

The reason for this can be the positional effects, in which different regions of the chromosome modulate transgene expression.

Functional levels of lentiviral-mediated WNT1 expression in the intestinal mesenchyme modulated transgene expression in the epithelium and resulted in a phenotypic readout.

Using the fluorescence marker protein Venus as a reporter, we observed that the lacO/lacI system could be amended to modulate transgene-expression in haematopoietic cells.

Moreover, the vector design allows simple substitution of the driving promoter to achieve tissue-specificity or to modulate expression ranges of inducible transgene expression.

It is well-documented that the small intestine displays cell signaling across its defined epithelial and mesenchymal cellular compartments [ 2, 12- 14], offering an ideal system to display lentiviral-mediated transgene expression to modulate mesenchymal-epithelial crosstalk.

Our findings highlight the efficient use of lentiviral-mediated transgene expression for modulating mesenchymal-epithelial interactions in vivo.

This biomaterial platform provides an opportunity to improve gene transfer by enhancing vector stability, while promoting and/or controlling cell-vector interactions in order to modulate the location and duration of transgene expression.

Our results are consistent with the reduced fibrogenesis observed following IGF1 induction in activated hepatic stellate cells after liver injury and the accelerated skeletal muscle regeneration by mIGF1 transgene expression, which rapidly modulates inflammatory cytokines and chemokines (Sanz et al., 2005; Pelosi et al., 2007).

However, few systems exist for mesenchymal transgene expression, which is required to modulate paracrine signals originating in the mesenchyme.