Taken together, these studies identify a novel role for FKBP52 in modulating toxicity of Aβ peptides.
Further studies will show whether these ligands are also involved in modulating toxicity of Aβ and may open the field for the development of a novel class of agents against Alzheimer's disease.
Moreover, STIP1 also modulates toxicity of Aβ peptides in models of Alzheimer's disease (Brehme et al., 2014; Ostapchenko et al., 2013).
Most Bt isolates produce more than one Cry toxin, thus, it is tempting to speculate that hetero-oligomerization of Cry toxins could have been selected in nature as a mechanism to modulate toxicity and insect specificity of these family of pore-forming toxins.
No general influence of the anionic compound in the ionic liquids on toxicity could be found, although they seem to modulate toxicity in some cases.
Much of the emerging evidence suggests that nutrition can modulate the toxicity of environmental pollutants, which may alter human risks associated with toxicant exposures.
First, the octapeptide sequences may modulate the toxicity of PrPSc.
We chose to study the toxic species of ataxin-1 that expresses an expanded polyQ repeat as our aim was to modulate the toxicity of this species using protein domains distal to the repeat.
Sb in drinking water has been reported to modulate the toxicity of As (Gebel 1999).
