Sentence examples for modulate these targets from inspiring English sources

This suggests that small molecules could be developed that modulate these targets in mammalian myotubes.

Our group used the proteomic approach to search for new chemotherapeutic leishmanial targets and to modulate these targets to control Leishmania infection.

Since HDAC4 negatively regulates transcription, it is unlikely to modulate these targets directly, as deletion would be predicted to result in increased expression.

Nevertheless, current drug research efforts continue to be almost exclusively focused on single protein targets and the identification of small molecules that can modulate these targets with high affinity (Schubert & Maher, 2012).

Further studies aimed at exploring the mechanisms by which OPNc modulates these target and interacting gene products will elucidate how it controls the proliferation of ovarian and prostate cancer cells.

We provide examples of monoclonal antibodies (mAbs) used to modulate the activity of these targets, and discuss approaches for using engineered versions of ligands and receptors themselves for therapeutic intervention in cancer.

Any modification in these targets could modulate the efficacy of IM and affect its mechanism of action.

In order to create a tunable dynamic range, homotropic allostery is employed to modulate the target specific binding.

Encapsulation into SSL did not modulate the targeting capacity of M26 35.

These doses usually allow to maintain steady-state plasma concentrations between 50 and 125 mg l−1 (DeVane, 2003), potentially in the range required to modulate the target (HDACs).

The targets of these pathways, how these targets are modulated, and how they are linked to the splicing machinery to regulate exon choice are key questions - though largely unresolved ones.