Ligands that specifically target individual subunits provide new tools for monitoring and modulating these networks, but are challenging to design due to the high sequence homology and structural plasticity of the Gα-binding surface.
We suggest that a better understanding of how the insula modulates the interaction between these networks is critical for elucidating both the cognitive impairments often associated with withdrawal and the performance-enhancing effects of nicotine administration.
It is also possible that other systems involved in maintaining protein homeostasis modulate the network by regulating synthesis and degradation of some of these chaperones.
The tumor suppressor DAB2IP contributes to modulate the network of information established between cancer cells and tumor microenvironment.
Likewise, filtering appliances can modulate the network bandwidth that can get eaten up in activities such as excessive video use.
If the PAX1 gene acts to modulate the network, it is therefore likely to affect more than one network member.
While the first approach can alter the underlying network structure permanently, the second one uses external control to modulate the network dynamics.
Because both environmental and genetic factors can modulate this network, ΔNp63 and other members of this network might contribute to phenotypic variation of ribosomopathies.
Thus, we conclude that 16/23 networks are activated in gastric cancer and that these networks are modulated as a result of down-regulated miRNAs expression.
