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Candida albicans isolates with different genomic background, designed as b and c karyotypes, have been previously shown to differentially modulate their response to macrophage candidacidal activity.
Although pDCs display an array of surface receptors able to modulate their response [5] [9], the molecular mechanisms for the negative regulation of their activity have not yet been completely elucidated and some of them in fact exhibit peculiar features.
These processes permit sensory subsystems to modulate their response levels to take into account spatial and temporal context.
However, Kimpo et al. have now obtained evidence that Purkinje cells can modulate their response to the instructions they receive from climbing fibres.
The contribution of key embryonic regulators such as SOX2 points to the conservation of critical developmental pathways in cancer cells, which modulate their response to the disruption of oncogenic signals.
Indeed, enteroendocrine cells appear to be able to modulate their response between pathogenic and nutrient sensing, secreting CXCL1/3 and IL-32 in response to flagellin and LPS, but not to fatty acids in vitro [ 46].
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Finally, MG PNs exhibit both excitatory and inhibitory spatial receptive fields and modulate their responses based on changes in stimulus geometry.
Undergraduate participants will modulate their responses when information is immediately available, but medical students do not show a similar adjustment.
Actually the terminal domains of versican may differentially control propagation of tumor cells and diversely modulate their responses to environmental hyaluronan [21].
Moreover, in vivo Ag85B treatment, induced the expression of 4-1BB on both CD4+ and CD8+ T cells (Fig. 7 C, Table 6), suggesting that in vivo 4-1BB engagement could modulate their responses.
We suggest that the absence of this effect is likely due to the medical students already possessing more objective knowledge of the diseases, so the additional information did not modulate their responses as much as the undergraduate students in Study 1.
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