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Histone variants can also receive PTMs, which can further modulate the unique effects that variants have on nucleosome dynamics.
6 This evidence suggests that GPCRs may act to modulate the unique fluid shear response observed in leukocytes.
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Additionally we would expect thatan abrupt reoxygenation could modulate the levels of this unique protein.
Intake of a quercetin-rich diet has been demonstrated to modulate the expression of 48 unique miRNAs.
In contrast, the PI3K pathway appears as a permissive pathway, which may serve as a switch to activate responsiveness or as a rheostat to modulate the intensity of a unique one-sided response of axonal growth [ 54 ].
EspV appears to modulate the actin cytoskeleton by a unique mechanism that is still undefined and expands the activities of cytoskeleton-targeting T3SS effectors beyond Rho GTPase signaling and pedestal formation.
Our findings may suggest that any drug affecting FC levels in SSc may actually modulate the GI tract in a unique way and could thus have potential as a drug that suppresses SSc GI disease.
Thus, the increased production of KG mediated by NADP-dependent isocitrate dehydrogenase (NADP-ICDH) and its decreased utilization via the TCA cycle confer a unique strategy to modulate the cellular redox environment.
Our data suggest that the CLR region provides channels with unique functional properties that modulate the rate of passive SR Ca2+ leak and confer on RyR1 and RyR3 distinctive [Ca2+]rest regulatory properties.
Our findings highlight a unique function for Prdm14 in regulating signalling and epigenetic states that modulate the balance between pluripotency and differentiation.
However, the unique structural and functional characteristics of mitochondria prohibit selective subcellular targeting of 3-BP to modulate the function of this organelle for therapeutic gain.
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