As a third non-mutually exclusive scenario based on the interactions data, in vitro GTPase assays and comparative studies with Ndel1 siRNA and dominant negative Dyn2, we speculate that Ndel1, by regulating Dyn2 GTPase activity, could modulate the trafficking, i.e. vesicle-mediated transport, of GluR1.
These changes are likely to modulate the trafficking properties of RIFIN proteins.
As each life stage exists within a highly controlled environment the trypanosome's ability to modulate the trafficking system has likely been lost.
If ERK1 can bind and phosphorylate VDAC, it could regulate channel activity by modulating the traffic of metabolites between mitochondria and cytosol.
Some lncRNAs influence homeostasis by modulating the traffic of proteins and hence the abundance of a protein in a particular subcellular compartment.
It participates in the immune reaction by modulating the trafficking of leukocytes, the maturation of epidermal DCs and the activation of T-cell in the antigen presentation (Mummert, 2005).
Such variances among NPC cases should therefore be taken into account when formulating therapeutic strategies aimed at modulating the trafficking of cholesterol or other sphingolipids.
The importance of CAR within epithelial junctions, where it behaves as an adhesion protein interacting with and potentially modulating the trafficking of key PDZ domain containing molecules, is becoming evident [4] [7].
These studies support emerging evidence that early endocytic defects impact NPC disease and suggest that such heterogeneity in NPC disease could result in diverse responses to therapeutic interventions aimed at modulating the trafficking of lipids.
The requirement for MAGI-1L function in regulating GLR-1 localization is abolished in mutants lacking GLR-2, suggesting that MAGI-1L responds to prior experience by specifically modulating the trafficking of GLR-1/GLR-2 heteromers via its interaction with GLR-2.
