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Much of the emerging evidence suggests that nutrition can modulate the toxicity of environmental pollutants, which may alter human risks associated with toxicant exposures.
Findings in knockout mice suggest that paraoxonase 1 may modulate the toxicity resulting from exposure to organophosphorus compounds.
Our observations indicate that drugs, which stimulate or block adrenoceptors and catecholamine release may lead to complications in drug therapy and modulate the toxicity or carcinogenicity of drugs that are substrates for the CYP1A1.
First, the octapeptide sequences may modulate the toxicity of PrPSc.
We chose to study the toxic species of ataxin-1 that expresses an expanded polyQ repeat as our aim was to modulate the toxicity of this species using protein domains distal to the repeat.
Sb in drinking water has been reported to modulate the toxicity of As (Gebel 1999).
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Furthermore, NLK modulates the toxicity of a mutant AR fragment via a mechanism that is independent of AR-mediated gene transcription.
This confirmed that ira2Δ HQ sensitivity is not due to a specific property of Ira2p and provides substantial support for our hypothesis that the level of active Ras signaling modulates the toxicity of HQ.
Yeast, as a eukaryotic model system, serves as an eminent tool to develop new methods to unravel pathways for modulating the toxicity of agents, especially those agents with unknown modes of action.
Previous studies reported that DJ-1 can modulate the aggregation and toxicity of aSyn.
Haptoglobin (Hp) is a protein whose primary function is to modulate the fate and toxicity of extracorpuscular hemoglobin [ 7].
More suggestions(15)
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