Sentence examples for modulate the specificity from inspiring English sources

It appears possible that intra- and extra-organismal stimuli modulate the specificity of the catalytic activity of dSETDB1, which results in gene-specific mono-, di- or tri-methylation of H3-K9.

We propose that this repetitive arrangement facilitates recombination of domains to modulate the specificity of the common function: adhesion to the host.

Adjuvants are known to modulate the specificity of antibodies elicited against some parasite antigens [19], [20].

As RRM extensions modulate the specificity of RNA binding, the binding affinity, and/or the accessibility of the RNA-binding surface for other nucleic acid-binding proteins, we hypothesized that the SF2/ASF N-terminal extension may influence the affinity of the protein for splicing substrates.

Since this VRK1 downregulation requires p53 dependent transcription [12], in this report we have used this VRK1 downregulation by p53 to determine the potential contribution of different acetyl transferase cofactors of p53 that can modulate the specificity of gene transcription, and for which VRK1 downregulation provides a functional assay.

Sequence conservation of functional residues is therefore less obvious for residues that modulate the specificity of biological function.

On this basis, they postulated that C-terminal tyrosine phosphorylation modulates the specificity of the Spry2 inhibition of different ERKs.

Because Fn conformational changes were previously shown to modulate the binding specificity of integrins [ 35– 39], we also examined altered integrin specificity as a potential mechanism of tumor-induced modified signaling.

Many studies reported that miRNA post-transcriptional editing could alter processing of some miRNAs [ 63] or modulate the target specificity of the mature miRNA [ 64].

Tissue-specific Myo5a isoforms are originated from alternative exon usage of the primary transcript, which in turn is thought to modulate the protein specificity for different cargoes within the cell [ 43].

In a similar fashion, MDR-selective compounds targeting P-gp-expressing cells might modulate the transport/substrate specificity of P-gp, which would result in the export, and eventual cellular depletion, of essential endogenous molecules.