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Restraints imposed by the histone arginines on the displacement of base pairs can modulate the sequence-dependent deformability of DNA and potentially contribute to the unique features of the different nucleosomes.
Bioactive food compounds (nutrients and phytochemicals) at pharmacological doses are emerging as a therapy to modulate the complex sequence of metabolic changes associated with skin and systemic aging.
We were interested in the sequence requirements of the diacetyl-lysine BET recognition and designed a systematic peptide array in which we modulated the spacer sequence and residue properties of residues located between the two Kac binding sites.
Because the translation machinery reads inosine as guanosine (G), the ADARs may recode transcripts, which results in a proteome that is divergent from the genome 1 4 and thus modulates the protein sequence and function of several gene products.
* Claim 7 tries to couch the findings in a mechanistic setting, claiming that TF levels modulate the effect of DNA sequence variation.
Spectrum Modulation by ACF Template: Steps (4 - 5) modulate the power spectrum of generated sequence of last iteration as P a according to ACF template.
In order to improve the SINR of the radar system and an acceptable BER of HP communication system, it is necessary to modulate the spectrum of radar sequences to make sure that the integrated energy over the frequency hopping channels is under acceptable level.
These alternative sequences modulate the biochemical and biological properties of B-Raf proteins.
Taken together with the results in Figure 7, these data suggest that although the PDZ binding domain is required for the interaction, both the exact sequence of the binding domain and upstream sequences may modulate the interactions of PDZ domain containing proteins.
Together, the topology and sequence can modulate the energy landscape and influence the rate at which the protein folds to the native conformation.
Bauer et al. applied TALENs to modulate the activity of an enhancer sequence critical for erythroid expression of BCL11A, a gene implicated in hemoglobin disorders 66, 67.
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