Our results show that it is possible to modulate the self-assembly process by modifying the composition of the mixed Langmuir monolayer precursor of the LB film.
The silk fibroin nanofibers with high β-sheet content were added into the silk fibroin solutions to modulate the self-assembly, and to directly induce water-insoluble scaffold formation after lyophilization.
It was even reported that Cu2+ and Zn2+ ions could modulate the self-association of PrP by binding to the octarepeat region and do so in a collaborative fashion despite their different binding affinities [34], [35].
16b We set out to examine the ability of dilute protein clusters (at concentrations that are much lower compared to those usually associated with molecular crowding) to modulate the self-assembly of peptide based gelators through templating and binding effects.
It is possible that estrogens, through either PELP1- or EIG121-mediated pathways, modulate the self-digestive activities of uterine endometrium and mammary gland tissues to accommodate the remodeling of endometrial tissues during the menstrual cycle and the lactation and involution of mammary glands.
In a study to determine whether the dietary polyphenols, curcumin, and piperine are able to modulate the self-renewal of normal and malignant breast stem cells, the effects of these compounds on mammosphere formation, expression of the breast stem cell marker aldehyde dehydrogenase (ALDH), and Wnt signaling were examined.
Taken together, these findings suggest that age-related increases in intestinal proliferative activity may be conserved from Drosophila to mammals, and that Drosophila is an excellent model system for the identification of regulatory factors that can modulate the self-renewal of stem cells during aging.
This effect was originally described for dendrimer micelles formation modulating the self-organization of amphiphilic carboxylates: Na+ forms bridging complexes with carboxylate groups, in contrast to K+ [3].
It was found that the electrostatic interactions in the membranes incorporating negatively (or positively) charged lipids are controlling the structural lamellar-nonlamellar transitions, i.e. the nature of these guest peptides, the peptide-MO ratio, and salt concentration play an important role in modulating the self-assembled nanostructure.
Bmi-1 may become a therapeutic target in CSCs, not only modulating the self-renewal potential of these cells, but also inhibiting EMT and preventing stem cells from acquiring invasive properties.
To our knowledge it is first time reported here that the mesoscale protein clusters achieved at very low protein concentrations at room temperature and at pH near physiological conditions can modulate the peptide self-assembly process.
