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Single nucleotide polymorphisms (SNPs) in the promoter and 3'-untranslated region (UTR) of COX-2 were previously reported to modulate the risks for prostate, colorectal, esophageal, gastric, bladder, biliary tract, and non-small-cell lung cancer [ 17, 19- 31].
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miRNA studies provide mechanistic insights into genetic regulations that may modulate the risk of ASD.
Current evidence suggests that immune processes modulate the risk for cardiac involvement in HIV-infected persons.
XRCC1 is a scaffold protein critical for BER for which polymorphisms modulate the risk of cancer.
Genetic variation in ion channel genes, such as CACNA1C and CADPS2, may modulate the risk of ASD [59 61].
Because glutathione S-transferases (GSTs) are the major detoxification enzymes which protect cells against oxidative stress, genetic variations in the GST gene may modulate the risk of POP.
Identify clinical factors that modulate the risk of progression to COPD among asthma patients using data extracted from electronic medical records.
Further investigations are necessary to clarify the possible long-term differences between oral anti-diabetic drugs in terms of genotoxicity and cytotoxicity, and how these can modulate the risk of developing diabetic complications in general and cancer in particular.
A genome-wide association study (GWAS) has recently identified a novel single nucleotide polymorphism (SNP) rs356182 at SNCA that can modulate the risk of Parkinson's disease (PD) in Caucasian ancestry.
Our main finding is that genetic interactions modulate the risk for T2D in the Ashkenazi case-control sample.
However, the majority of women have no obvious functional or anatomic risk factors predisposing them to ASB, which suggests that genetic factors may modulate the risk of acquiring ASB.
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