Sentence examples for modulate the regulation from inspiring English sources

Of these proteins Catenin delta-1, Occludin, TJP-1 and TJP-2 have been described as genuine Src kinase substrates; the phosphorylation of the aforementioned sites has been shown to modulate the regulation of cell-cell adhesions as well as the formation of tight junctions [45], [49], [50].

They may also modulate the regulation of higher order chromatin structure.

For that reason we have been studying whether HLA-B27 would modulate the regulation or activation of these signalling molecules after stimulation with LPS.

As a critical part of regulatory networks in innate immunity, the dysregulation of some specific miRNAs would modulate the regulation of inflammatory in stimulated immune cells.

We propose that the activation or silencing of intragenic transcriptional enhancers can modulate the regulation of the host gene through a local change of the chromatin.

Expression of 18 out of 45 TFs, whose RE were enriched in the p53-regulated promoters, was affected upon p53 activation by nutlin3a treatment, suggesting that changes in their expression might in turn modulate the regulation of p53 targets.

Additionally, as hypophosphosrylation of Akt modulates the regulation of FOXO transcription factors [27], [28], we also observed that FOXO1 is upregulated in presence of p19 (Figure 4D).

A similar mechanism has been described in C. elegans where hypophosphosrylation of Akt modulates the regulation of FOXO transcription factors [27], [28], causing G1/S arrest that leads to a reversible cellular quiescence state [31], [32].

Airway dendritic cells are key regulators of pulmonary immune responses, and in the human lung, dendritic cells continuously present antigenic information from the airways to the pulmonary lymph nodes, thereby modulating the regulation of immune responses [ 62].

A recent study revealed that the bark extract of E. ulmoides prevents neurodegenerative diseases such as AD by modulating the regulation of cleaved poly (ADP ribose) polymerase (PARP), cleaved caspase 3, Bcl-2, and Bcl-xL via inhibition of JNK, p38 MAPK, ERK1/2, and PI3K/AKT signaling in H2O2-treated human SH-SY5Y neuroblastoma cells [ 79].

The global regulator can modulate the local regulation by (i) binding directly to DNA, (ii) disturbing the local regulator binding.