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Indeed, epithelial cells can secrete an array of proinflammatory molecules that modulate the recruitment and functioning of immune and inflammatory cells [1].
Various factors in the tumor microenvironment can modulate the recruitment and retention of BM-derived cells during the development of the tumor vasculature [37].
Thus, one way that menin regulates expression of Hoxa9 and other Hoxa cluster genes may be to modulate the recruitment of endogenous MLL and MLL-AF9 to a particular locus to alter histone modifications.
Alternatively, since attachment style can also influence the formation of "mental models" of others [10], [25], [26], it might primarily modulate the recruitment of higher-level cortical regions associated with mentalizing and theory of mind such as superior temporal sulcus (STS) and anterior cingulate cortex [27].
It is possible that β-Arrestin 2, once it is recruited to the active CXCR4 [48], [48] may indirectly regulate the phosphorylation of β-Arrestin 1 through the downstream mediators phospho-Erk 1/2 [50], and by this mechanism modulate the recruitment of clathrin and/or the ubiquitin ligase AIP4 [51], [51].
Alternatively, Nampt may modulate the recruitment of DDR factors to the site of DNA damage, and this process is independent of Nampt enzymatic activity.
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Complementary studies of inflammation in Drosophila embryos and zebrafish larvae allow us to live image the wound inflammatory response and provide opportunities to dissect the genetics of inflammatory cell recruitment to wounds, which in turn may allow us to identify gene targets for therapeutically modulating the recruitment of inflammatory cells and thus improving adult healing.
We tested the ability of NF-Y binding in modulating the recruitment of different modified histones onto its target DNA also in muscle of mdx mice that represent an animal model for human Duchenne and Becker muscular dystrophy.
A recent study demonstrated that PlGF, a ligand for VEGFR1 as well as Neuropilins 1 and 2 (NRP1/2), significantly modulated the recruitment of macrophages, tumor growth and local invasion [7].
Therefore, it is tempting to speculate that sHLA-G, by dampening CXCR3 mediated chemotaxis, modulates the recruitment of these cell populations to granulomatous mycobacterial lesions, perhaps limiting excessive tissue damage.
and suggests that these RJ-derived medium chain fatty acids, structurally entirely different from E2, mediate estrogen signaling, at least in part, by modulating the recruitment of ERα, ERβ and co activators to target genes (Fig.6.II).
More suggestions(15)
influence the recruitment
modulate the risk
modulate the volume
modulate the wavelength
modulate the effectiveness
modulate the bone
modulate the speed
modulate the degree
modulate the cation
modulate the light
modulate the effect
modulate the histone
modulate the invasion-metastasis
modulate the host
modulate the response
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