Sentence examples for modulate the reactivity from inspiring English sources

The preparation of a novel series of N-aryl CBI derivatives in which an aryl substituent could be used to predictably modulate the reactivity of the resulting CC-1065/duocarmycin CC-1065/duocarmycinalkylationsubunitled analogueextensisn to a unique series of N-alkenyl detailedves is reported.

This work also suggests that domain-domain interactions within Spy0128 may modulate the reactivity of residues within each active site.

These results illustrate how variations in the properties of the substrate can modulate the reactivity of a monooxygenase.

We reasoned then that we could modulate the reactivity of the 3-carboxamide by introducing substituents with different electronic properties on the heterocyclic scaffold.

Mechanistically, engaging the amino terminus may suppress cyclizations and other side reactions and may modulate the reactivity of the carboxy group via inductive effects.

This modification was dependent on Cys431, His433 and Glu444, suggesting that His433 and Glu444 indeed modulate the reactivity of Cys431 and constitute a catalytic triad.

We expected that modulating the reactivity of these compounds would impact their stability.

2-Cyanopyrrolidines were described as selective cathepsin L inhibitors, the most potent compound (51, Ki=5.3 µmol/L, Fig. 8) was reported to be selective against cathepsin B. The 1,3,5-triazine-2-carbonitrile 1,3,5-triazine-2-carbonitrile 1,3,5-triazine-2-carbonitrile 1,3,5-triazine-2-carbonitrileg potent inhibitorepresents 52 (Fig. 8; Ki=9 nmol/L, rhodesanothernmol/L, capproach L).

In Anabaena Flavodoxin both the protein environment and the redox state contribute to modulate the chemical reactivity of the isoalloxazine ring.

Apart from extending the SARs of the 5-deazaflavins through synthesis and testing of more analogues, the most important aspect would be to modulate the electrophilic reactivity of the system.

Therefore, in contrast to the canonical HOs, where the interactions of the coordinated FeIII OOH with the hydrogen-bonding network modulate the heme reactivity, in the noncanonical IsdG-like proteins this is achieved through sterically induced heme ruffling.