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We identified realistic conditions under which mRNA lifetime and transcriptional pauses modulate the protein expression noise initially introduced by the promoter architecture.
Although not tested in this study, the different charges carried by these proteins may be caused by phosphorylation, since phosphorylated forms of these proteins have been observed and are known to modulate the protein activity [11], [22], [23].
Since binding of 6AP and GA to the ribosome is RNA-dependent and exhibits no inhibitory effect on protein synthesis, we wondered if these drugs might modulate the protein folding activity of the ribosome.
Furthermore, we have found that ligands modulate the protein function by redistributing flux along multiple pathways.
Therefore, we examined the ability of thioridazine to modulate the protein stabilities of c-FLIP(L) and Mcl-1.
On the other hand, since glycans primarily modulate the protein function they can vary much more freely.
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The goal was to identify chromosomal loci that modulate the protein-level regulatory activity of a particular RBP.
Sp1 is subjected to several PTMs, which modulates the protein level, the DNA-binding activity or the transactivation potential of Sp1 (Chang and Hung, 2012).
Therefore, disulfide bond reduction modulates the protein folding/misfolding landscape by entropically stabilizing disordered states, including the U and transition state of aggregation.
It is possible that the C-terminal domain modulates the protein activity of dRecQ4, possibly via amino acids modifications and/or interactions with other proteins.
To explore how PUM2 stabilizes Aurora-A, we determined whether the interactions between Aurora-A and PUM2 are necessary for modulating the protein stability of Aurora-A.
More suggestions(15)
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modulate the histone
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modulate the host
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