Sentence examples for modulate the postsynaptic from inspiring English sources

Interestingly, variations of these quantities modulate the postsynaptic current.

are able to modulate the postsynaptic responses with further transmission to supraspinal sites (thalamus, anterior cingulated cortex, insular cortex, and somatosensory cortex) via the ascending pathways [ 22, 24, 25].The simplest form of plasticity in nervous systems is that repeated noxious stimulation may lead to habituation (decreased response) or sensitization (increased response) [ 26].

These gain- and loss-of-function data show that TRIM3 modulates the postsynaptic levels of GKAP and Shank1 scaffolds endogenously in neurons.

These data indicate that altering zinc levels can have dramatic effects on PSDs by modulating the postsynaptic levels of Zn2+-sensitive ProSAP/Shank isoforms.

Ultimately, both the BK and SK2 channels may be required to modulate the strength of postsynaptic inhibition.

As well as STD, the facilitation mechanism is able to modulate the intensity of the postsynaptic response in a nonlinear manner for given presynaptic conditions.

To examine whether a drug acted via pre- or postsynaptic mechanisms to modulate the inspiratory output from XII MNs, the effect of the drug on miniature excitatory postsynaptic currents (EPSCs) that occur in the presence of tetrodotoxin (TTX, 1 µM), strychnine (10 µM) and bicuculline (10 µM) (all bath applied) was assessed.

Second, they mediate or modulate the insertion of additional AMPA receptors into the postsynaptic membrane.

Zn2+ has been shown to be highly concentrated in PSDs of excitatory synapses in the central nervous system and to be able to significantly modulate the structure of the protein meshwork underneath the postsynaptic membrane within a few minutes.

In this scenario, our observations indicate that PC axons modulate the balance between synthesis and degradation of PNN components in the postsynaptic DCN neurons.

However, presynaptic nicotinic acetylcholine receptors have been shown to modulate the release of glutamate in the VTA, which via postsynaptic NMDA receptors regulate accumbal dopamine release (Schilström et al. 1998; Schilström et al. 2000).